ANISOMELIC ACID* James A. Marshall and Bradley S. DeHoff Department of Chemistry, University of South Carolina Columbia, South Carolina 29208 (Received in UK 30 January 1987) Abstract. The stereoselective total synthesis of ( )-anisomelic acid (34) has been achieved starting from aldehyde 7, the ozonolysis product of geranyl acetate.

Anisomelic acid, is one of the major compounds in Anisomeles malabarica (L.) R. Br., is a cembrane type diterpenoid, which can be synthesized chemically. Anisomeles malabarica (Lamiaceae) is an aromatic, densely pubescent, perennial herb, 1.2-2 m in height. The leaves of Anisomeles malabarica are used against colic, convulsion and tetanus. 2.

Many people — about 20% of the U.S. population, according to the National Institutes of Heal Amino acids may sound familiar from your high school biology class, but did you know that your body needs them to survive? In fact, there are two different types of amino acids — essential and non-essential — that are important for your bod Folic acid is a synthetic form of one of the family of B vitamins that's added to foods and can be taken as a supplement. Folic acid mimics the naturally occurring element, folate. Alcohol ― scientifically referred to as ethanol in many cases ― is neither an acid nor a base. However, it can act as either, depending on what it is combined with and what reaction you are looking to achieve.

Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells. The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- and duration-dependent manner. Acridine Orange & Ethidium Bromide (AO & EB) and Hoechst 33258 staining Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells.The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- … Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles mal - abarica . Recently, we have studied the mode of action of AA-mediated apoptosis A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas Rajendran Senthilkumar , Yury Brusentsev , +4 authors J. Eriksson Scientific Reports Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells. Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. CAM, cIAP2, HPV: 5 : 2013: Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica.

In this work, we describe the development of a folic acid (FA)-targeted AA delivery system using chitosan-coated rod-shaped mesoporous silica particles (Chitosan-NR-MSP).

Anisomelic acid | C20H26O4 | CID 5358705 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

The in ovo chick embryo chorioallantoic membrane (CAM) assay showed that anisomelic acid inhibited the tumor growth of the cervical cancer SiHa cells. AA is revealed to hold a novel action modality based on specific targeting of the HPV oncoproteins, which restores p53-mediated growth arrest and induces apoptosis by terminating E6-mediated cIAP2 stabilization. Dealing with heartburn and stomach acid troubles is an uncomfortable condition that nearly everyone experiences from time. For some people, it's a sign of gastroesophageal reflux disease (GERD).

Preethy C.P., et al., 2013, “Analysis of the cytotoxic potential of anisomelic acid isolated from Anisomeles malabarica,” Scientia pharmaceutica; 81(2): 559-566. [ Web Reference ] Singh I., et al., 2010, “Anticonvulsant potential of Anisomeles malabarica leaves against experimentally induced convulsions in rats,” International Journal of Green Pharmacy; 4(3): 199-205.

The leaves of Anisomeles malabarica are used against colic, convulsion and tetanus. 2.

petroleum ether extract of plant contains a triterpenic acid known as betulinic acid [3] while the hexane extract consists of β-sitosterol and diterpenoids (ovatodiolide and anisomelic acid) [4]. The aerial parts contain anisomelolide, malabaric acid, 2-acetoxymalabaric acid, anisomelyl acetate, anisomelol and … Pharmacy AA abbreviation meaning defined here.
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It is used in folk medicine in the treatment of diverse conditions such as inflammatory skin diseases, Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Rajendran Senthilkumar1, Yury Brusentsev2, Preethy Paul1, Fang Cheng1, Maria Sippola-Thiele1, Patrik Eklund2 and John E Eriksson1 1Turku Centre of Biotechnology, Finland 2Abo Akademi University, Finland Targeted delivery of a new anticancer compound Anisomelic acid using chitosan-coated porous silica nanorods for an enhanced apoptotic effect in vitro by Rajendran Senthilkumar a, Didem Şen Karamanb, Preethy Paula, Emma M. Björkc, Magnus Odénc, John E. Eriksson*,a and Jessica M. Rosenholm*,b Preethy C.P., et al., 2013, “Analysis of the cytotoxic potential of anisomelic acid isolated from Anisomeles malabarica,” Scientia pharmaceutica; 81(2): 559-566. [ Web Reference ] Singh I., et al., 2010, “Anticonvulsant potential of Anisomeles malabarica leaves against experimentally induced convulsions in rats,” International Journal of Green Pharmacy; 4(3): 199-205.

Anisomeles malabarica (Lamiaceae) is an aromatic, densely pubescent, perennial herb, 1.2-2 m in height. The leaves of Anisomeles malabarica are used against colic, convulsion and tetanus. 2.
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1986-01-01

with Prof. Erikson's team). Education. March 2018 to to-date Research Associate, Åbo Akademi University, Turku, Finland. Feb 2017 to Dec 2017 Research Associate, Albany State University, Albany, Georgia, USA. Dec-2010 to Paul P, Kumar Rajendran S*, Peuhu E*, Alshatwi AA, Mohammad AA, Hietanen S, and Eriksson JE (2014): Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. Biochemical Pharmacology.

1987-01-01 · Anisomelic acid is found in the South Indian medicinal plant Amsomeles malabauta R.Br.l, whereas the lobohedleolides are constituents of the soft coral Lobophytum hedlejt Whitelegge, which inhabits a region of Okinawa.2 Lobohedleolide inhibits growth of Hella cells in vitro at 5 ug/mL.2 No specific biological activity has been reported for the other members of the triad. anisomelic acid (I) lobohedleolide (II) (7E)-lobohedleolide (111) The presence of a conjugated acid moiety at

The aerial parts contain anisomelolide, malabaric acid, 2-acetoxymalabaric acid, anisomelyl acetate, anisomelol and anisomelin [5]. Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica . By Christo Paul Preethy. Cite .

Characterization revealed the presence of phyto compound such as aniso melic acid, 22 May 2019 as anisomelic acid, anisomeloide, ovatodiolide, 2-acetoxymalabaric acid, anisomelyl acetate anisomelin, betulinic acid, citral, gerainic acid, 24 Nov 2017 Novel action modality of the diterpenoid anisomelic acid causes depletion · of E6 and E7 viral oncoproteins in HPV-transformed cervical Aldrich-331562; Cyclohexanepentanoic acid 0.98; CAS No.: 5962-88-9; Synonyms: 5-Cyclohexylvaleric acid; Linear Formula: C6H11(CH2)4CO2H; Empirical 30 Jul 2018 Title: Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas. Yury Brusentsev, Abo may be due to the presence of volatile compounds such as anisomelic acid, betulinic acid, citral, gerainic acid and ovatodiolide in the plant extract (Guha Bakshi Pharmaceutical compositions of anisomelic acid and their use Download PDF pharmaceutical composition: cells: antiviral: apoptosis: anisomelic acid; Prior art Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas. R Senthilkumar, Yury Brusentsev, Preethy Paul, Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect. Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect.